乳腺癌治疗中的营养药:机制性见解和治疗潜力
Srinivas Ganjipete1, Basavana Gowda Hosur Dinesh1, Sunil Kumar Bandral1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Banglore, 560054, Karnataka, India.
International journal of biological macromolecules
|November 11, 2025
概括
自然化合物,包括植物化学物质和海洋剂,通过向关键途径并表现出抗癌作用,对乳腺癌 (BC) 治疗有希望. 纳米技术和个性化的方法可以克服这些营养药的交付挑战.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 乳腺癌 (BC) 是癌症死亡的主要原因,在治疗疗效,耐药性和毒性方面存在持续的挑战,特别是三阴性BC.
- 来自自然来源的营养药物为BC预防和治疗提供了多目标,低毒性的治疗潜力.
- 现有疗法面临局限性,需要探索新的药物和策略.
研究的目的:
- 审查自然化合物在治疗乳腺癌中的机械功能和治疗潜力.
- 探索植物化学物质和海洋衍生剂的抗癌活动和机制.
- 讨论临床翻译的挑战和潜在的解决方案,如纳米技术和个性化医学.
主要方法:
- 对自然化合物,植物化学品,海洋剂及其对乳腺癌的影响研究的文献综述.
- 对作用机制的分析,包括对致癌途径的调制 (PI3K/AKT/mTOR,Wnt/β-catenin,Notch,NFκB).
- 对抗癌症活动的检查,如亡诱导,抗血管生成,抗转移和免疫反应调节.
主要成果:
- 植物化学物质 (黄素,白醇,素,EGCG,贝卡林) 和海洋衍生剂显示出显著的抗乳腺癌特性.
- 这些化合物向关键的瘤途径,并表现出各种抗癌作用,包括诱导亡和抑制转移.
- 诸如低生物利用率和快速新陈代谢等挑战需要先进的输送系统.
结论:
- 自然化合物,包括植物化学品和海洋剂,代表了乳腺癌管理的有前途的治疗候选者.
- 基于纳米技术的输送系统对于提高这些营养药的疗效至关重要.
- 进一步的研究和临床评估对于将这些药物纳入瘤实践和开发个性化治疗策略至关重要.
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