瘤发生中的NR1D1:双重作用,机制和治疗向
Zhuangwei Lv1, Ruohao Yang2, Jinhua Wu3
1School of Forensic Medicine, Xinxiang Medical University, Xinxiang, China.
Gene
|November 11, 2025
概括
核受体子家族1,D组,成员1 (NR1D1) 在癌症中具有双重作用,作为瘤抑制剂或瘤基因. 这篇评论探讨了NR1D1的情况.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 时间生物学 时间生物学
背景情况:
- 核受体子家族1,D组,成员1 (NR1D1),也称为REV-ERBα,是核心的昼夜调节器.
- NR1D1在癌症中表现出取决于背景的双重作用,作为瘤抑制剂或瘤基因起作用.
- 了解NR1D1的复杂作用对于开发新型癌症疗法至关重要.
研究的目的:
- 综合目前关于NR1D1对癌症关键瘤性途径的调节的证据.
- 突出NR1D1作为预后生物标志物和治疗点的潜力.
- 讨论针对癌症治疗的NR1D1的挑战和机会.
主要方法:
- 关于研究癌症中的NR1D1的综合文献综述.
- 对NR1D1参与DNA修复,免疫调节,新陈代谢和信号通路 (PI3K/AKT,JAK/STAT) 的分析.
- 对药理学NR1D1调节器的临床前数据的评估.
主要成果:
- NR1D1调节关键的瘤性通路,包括DNA修复,cGAS-STING和NLRP3炎症体通路,新陈代谢以及PI3K/AKT和JAK/STAT信号传递.
- 药理学调节器的NR1D1已经证明了临床前的疗效.
- NR1D1 作为各种癌症的潜在预后生物标志物.
结论:
- NR1D1是癌症发展和进展的重要调节者,具有作为生物标志物和治疗标的潜力.
- 针对NR1D1,特别是通过组合疗法,为癌症治疗提供了有前途的新途径.
- 需要进一步的研究来克服NR1D1向疗法的挑战.
相关概念视频
02:23Abnormal Proliferation
5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
01:24Small GTPases - Ras and Rho
5.2K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
Three regulatory proteins control their activity:
5.2K
01:31Transducer Mechanism: Nuclear Receptors
2.3K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
2.3K
02:38Mitogens and the Cell Cycle
7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K
01:20The Retinoblastoma Gene
4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
01:23Negative Regulator Molecules
38.2K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.2K