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[在抗VEGF治疗视网膜静脉封闭后的附带循环的特征]

R Y Wang¹, P Chen¹, J H Zhang²

¹Eye Center of Ophthalmology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology

|November 11, 2025

概括

抗VEGF治疗抑制了中央视网膜静脉封闭 (CRVO) 中的附带血管形成,但没有分支视网膜静脉封闭 (BRVO). 糖尿病和高血压等系统性因素在任何RVO类型中都没有显著影响附带形成.

科学领域:

眼科医生眼科眼科
血管生物学血管生物学
视网膜疾病视网膜疾病

背景情况:

视网膜静脉封闭 (RVO) 是视力丧失的一个重要原因.
担保船舶形成是RVO的一个关键补偿机制.
抗血管内皮生长因子 (抗VEGF) 治疗对RVO附带担保的影响尚未完全理解.

研究的目的:

在接受抗VEGF治疗的RVO患者中调查附带血管的形成.
分析不同抗VEGF治疗方案 (无注射,1+PRN,3+PRN) 对担保的影响.
评估系统因素 (糖尿病,高血压) 在附带血管发育中的作用.

主要方法:

对157名RVO患者 (87名BRVO,70名CRVO) 进行了回顾性队列研究,这些患者因斑点而接受拉尼比祖马布治疗.
患者被分为无注射,1+PRN或3+PRN治疗组.
在两年内,通过 fundus 摄影和光素血管学来评估并发循环形成;统计分析包括奇方和费舍尔的精确测试.

主要成果:

在62.1%的BRVO患者 (中位时间172天) 和18.6%的CRVO患者 (中位时间333.5天) 中出现了附带循环.
在CRVO中,在治疗组之间观察到附带形成的统计学上显著差异 (P=0.022),抗VEGF治疗似乎抑制了它.
无论是糖尿病还是高血压,都没有显著影响BRVO或CRVO患者的附带形成.

结论:

抗VEGF治疗显著抑制了CRVO患者的附带血管形成.
在BRVO患者中,抗VEGF治疗没有显著影响附带血管形成.
糖尿病和高血压等系统性因素在任何RVO亚型中都没有显著影响附带形成.

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