在胚胎转移的修改自然周期中,血清中叶血清孕激素度:一项前性盲目的研究
Elena Labarta1, Cristina Rodríguez-Varela1, Carmina Vidal2
1Human Reproduction Department, IVI RMA Valencia, Valencia, Spain; IVI Foundation - IIS La Fe, Valencia, Spain.
Reproductive biomedicine online
|November 11, 2025
概括
在经过修改的自然周期冷胚胎移植 (mNC-FET) 周期中,hCG触发和质期支持 (LPS),血清孕激素水平充足,并没有影响怀孕成功. 在这个特定的试管婴儿协议中,不需要定期监测孕激素.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
背景情况:
- 修改自然循环冷胚胎移植 (mNC-FET) 是一种常见的试管婴儿协议.
- 质阶段支持 (LPS) 是mNC-FET的标准,通常涉及孕激素补充.
- 在本协议中,血清中叶血清孕激素度对怀孕结果的作用需要澄清.
研究的目的:
- 在mNC-FET循环中调查血清中叶血清孕激素度与怀孕结果之间的关联.
- 确定是否需要在mNC-FET中进行常规的孕激素监测,以hCG触发和LPS.
主要方法:
- 对241名接受mNC-FET治疗的不孕症患者进行了前性,盲目的,单中心的队列研究.
- 用hCG触发排卵;用微化阴道孕激素给药的LPS.
- 在胚胎移植后2小时内测量血清孕激素.
主要成果:
- 平均血清孕激素为26.2 ± 9.0 ng/ml,99%的患者超过了>10 ng/ml的值.
- 在孕激素四分位数中,持续怀孕率 (P = 0.74) 或活产率 (P = 0.66) 没有显著差异.
- 在多变量分析 (aOR 0.86) 中,中叶血清孕激素与正在进行的怀孕没有显著的关联.
结论:
- 在具有hCG触发和LPS的mNC-FET循环中,血清中叶血清孕激素度足够.
- 在这种特定的试管婴儿环境中,血清孕水平不会影响怀孕结果.
- 对于接受hCG触发和LPS的mNC-FET的患者,常规的孕激素监测被认为是不必要的.
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