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Updated: Jan 11, 2026

Methylated RNA Immunoprecipitation Assay to Study m5C Modification in Arabidopsis
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5-甲基细胞氨酸不是哺乳动物细胞中普遍存在的RNA修饰

Jasmin A Dehnen1, Alexander V Gopanenko1, Carola Scholz1

  • 1Institute of Molecular Biology (IMB), Mainz, Germany.

Nature communications
|November 11, 2025
PubMed
概括

哺乳动物5-formylcytidine (f5C) 主要在线粒体tRNA中发现,而不是mRNA. ALKBH1酶调解了这种修饰,挑战了关于其作用和位置的先前假设.

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
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