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在ketoconazole洗发水中评估Psidium guajava L.叶片提取物的抗菌疗效

Fuad Al-Rimawi¹, Hamada Imtara², Jehad Abbadi³

¹Chemistry Department, Faculty of Science and Technology, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine.

Scientific reports

|November 11, 2025

概括

Psidium guajava L. 叶子提取物显示出强大的抗菌活性,有效地抑制了香配方中的微生物生长. 这种天然防腐剂为合成选项提供了安全的替代品,在稳定性和防腐剂测试中显示出显著的有效性.

科学领域:

药理学和植物化学
化品科学化品科学
微生物学微生物学

背景情况:

化品中的合成防腐剂引发了健康问题,推动了对天然替代品的需求.
瓜 (guava) 树叶具有已知的抗菌性质.
为个人护理产品开发有效的天然防腐剂至关重要.

研究的目的:

为了评估乙醇Psidium guajava L.叶片提取物在洗发水配方中的抗菌效果和稳定性,作为天然防腐剂.
为了比较其与合成防腐剂的性能.
确定负责抗微生物活性的关键生物活性化合物.

主要方法:

乙醇提取物的植物化学查和HPLC分析.
将提取物纳入各种度的洗发水基 (0.5%10%).
防腐剂有效性测试 (USP/BP指南) 和加速稳定性研究 (40°C/75%RH3个月).

主要成果:

10%的Psidium guajava L.提取物在28天内完全抑制了微生物的生长 (大肠杆菌, Pseudomonas aeruginosa,金黄色葡萄球菌,白菌, Aspergillus brasiliensis).
稳定性测试证实了洗发水配方的物理完整性和可纳的化学稳定性.
提取物满足并超过了USP/BP对防腐剂有效性的接受标准.

结论:

乙醇 Psidium guajava L. 叶片提取物在化品配方中显示出作为天然防腐剂的巨大潜力.
提取物在测试的洗发水配方中是有效和物理稳定的.
需要进一步的研究来评估这种天然防腐剂的长期稳定性和安全性.

关键词:

这种植物是Psidium guajava L. 的产物.抗菌剂是一种抗菌剂.凯托可纳醇洗发水可以使用.植物化学分析植物化学分析稳定的稳定性稳定的稳定性

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