海马雄性怀孕的细胞和分子机制
Yali Liu1,2,3, Han Jiang1,2,3, Yuanxiang Miao4,5
1CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangdong Provincial Key Laboratory of Applied Marine Biology Chinese Academy of Sciences, Guangzhou, China.
Nature ecology & evolution
|November 11, 2025
概括
雄性海马在一个独特的繁殖袋中携带幼,这种袋子独立于哺乳动物怀孕而进化. 这项研究揭示了这种令人着迷的性别角色逆转和囊发育背后的遗传和细胞机制.
科学领域:
- 进化生物学是进化的生物学.
- 发育生物学是发展生物学.
- 进行比较的基因组学.
背景情况:
- 辛格纳类动物 (海马和亲属) 呈现反向的性角色,雄性提供父母的照顾.
- 雄性怀孕在syngnathids是由一个新的繁殖袋支持,类似于哺乳动物的子宫/胎盘,但有不同的起源.
- 了解辛格纳囊进化为人们提供了关于父母照顾的融合进化的见解.
研究的目的:
- 调查从产卵到雄性怀孕的进化过渡在syngnathids.
- 与哺乳动物系统的同胞胎位状类似的家长护理进行比较.
- 确定细胞和遗传机制驱动育种袋的发展和功能.
主要方法:
- 比较单细胞多基因组学和基因组学分析跨综合类物种.
- 在体内实验中测试原生细胞诱导囊袋的潜力.
- 在囊组织和专门的皮肤贴片中分析基因表达.
主要成果:
- 一个特定的表皮原生群体表达雄激素触发育卵袋的形成.
- 囊袋的功能是通过招募具有正体哺乳动物子宫基因的伪胎盘细胞来确保的.
- 专门的男性皮肤贴片表达新型基因 (pastns,syn-lectins) 容纳粘性卵.
结论:
- 雄性怀孕的Syngnathid通过与哺乳动物怀孕不同的机制进化.
- 雄激素驱动的囊本体和专门细胞的招募是关键的 syngnathid 家长护理.
- 这些适应驱动了同类的繁殖袋的多样性和复杂性.
相关概念视频
Spermatogenesis
121.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.5K
Spermatogenesis
8.8K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.8K
Fertilization
89.4K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
89.4K
Sperm Transport
3.1K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
The maturation phase occurs in the epididymis, where sperm...
3.1K
Gonadal and Placental Hormones
2.7K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
2.7K


