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Updated: Jan 11, 2026

Precise Phage Mutagenesis with NgTET-Assisted CRISPR-Cas Systems
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一种菌体编码的抗CRISPR蛋白选择宿主酶以防止III型CRISPR免疫

Katie A Johnson1, Hemant N Goswami2, Ryan J Catchpole1

  • 1University of Georgia, Athens, GA, USA.

Nature microbiology
|November 11, 2025
PubMed
概括

菌体使用抗CRISPR蛋白来逃避细菌的CRISPR免疫力. 研究人员发现了AcrIIIA2,它劫持了宿主酶以阻止Streptococcus thermophilus型III-CRISPR-Cas系统,揭示了一个新的菌体防御策略.

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