维生素D与口腔癌的关系
Chrispinus Hakimu Mumena1,2, Nuraly S Akimbekov3,4,5, Rajabu Sasi6
1The Copperbelt University, School of Medicine, Department of Dental Clinical Sciences, Ndola, Zambia. Chrispinus.mumena@cbu.ac.zm.
Advances in experimental medicine and biology
|November 11, 2025
概括
维生素D在改善口腔癌预后和治疗结果方面显著有前途. 研究表明,它有可能提高化疗敏感性和患者的生活质量,这表明它在治疗口腔状细胞癌 (OSCC) 中的作用.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- 口腔癌,特别是口腔状细胞癌 (OSCC),由于对细胞死亡和治疗的抵抗,具有很高的死亡率和复发率.
- 目前的OSCC预后参数由于其可变的生物行为而存在局限性.
- 维生素D对抗口腔癌具有显著的生物效应,包括抗增殖,抗侵袭和诱导亡的特性.
研究的目的:
- 调查维生素D及其相关基因多态性在口腔癌的预后价值.
- 探索维生素D在增强OSCC治疗敏感性和改善患者生活质量的潜力.
主要方法:
- 对维生素D对OSCC的生物效应进行现有研究的审查.
- 分析维生素D水平,VDR,CYP24A1和CYP27B1多态性之间的关联,以及OSCC的预后.
- 评估维生素D对口腔癌患者化疗敏感性和生活质量的影响.
主要成果:
- 维生素D表现出抗增殖,抗侵袭,抗血管性作用,并诱导OSCC的亡.
- 维生素D增强OSCC细胞对化疗的敏感性,即使在耐药瘤中也是如此.
- 低维生素D水平和特定的VDR,CYP24A1和CYP27B1多态性与增加口腔癌风险和侵袭性疾病有关.
结论:
- 维生素D对口腔癌患者具有显著的预后价值.
- 测量血清维生素D水平和识别口腔癌细胞中的VDR,CYP24A1和CYP27B1可以改善预后预测和管理.
- 维生素D的使用可以改善无法手术的口腔癌患者的生活质量和化学敏感性.
关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.补充因子 D D人类人类人类.口腔的新生体 嘴巴的新生体预后 预后 预测 预测生活质量生活的质量.调节的细胞死亡.维生素D 维生素D是一种维生素.维生素D缺乏症是因为缺乏维生素D.更多相关视频
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
11.0K
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
9.8K
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
7.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.5K
01:25Role of Vitamins in Maintaining Bone Health
5.0K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.0K
02:59Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
01:22Connective Tissue Cell Types
4.0K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.0K
01:03Rous Sarcoma Virus (RSV) and Cancer
6.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.1K
01:30Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K