沉重的酒精使用加剧了外围动脉疾病中的骨肌病
Panagiotis Koutakis1,2, Emma Fletcher3, Evlampia Papoutsi4
1Department of Cellular and Integrative Physiology, University of Nebraska at Medical Center, Omaha, NE, USA. pkoutakis@unmc.edu.
GeroScience
|November 11, 2025
概括
周围动脉疾病 (PAD) 与酒精使用障碍 (AUD) 结合,显著恶化骨肌损伤和功能. 这项研究表明,阿尔代脱酶2 (ALDH2) 功能障碍有助于PAD-AUD患者的肌肉退化.
科学领域:
- 血管生物学 血管生物学
- 骨肌肉生理学 骨肌肉生理学
- 与酒精有关的疾病.
背景情况:
- 周围动脉疾病 (PAD) 通过氧化应激和线粒体问题引起骨肌肉功能障碍.
- 慢性酒精滥用独立导致类似的肌肉损伤.
- PAD和酒精使用障碍 (AUD) 对骨肌肉的综合影响尚不清楚.
研究的目的:
- 为了研究AUD如何加剧PAD相关的骨肌病理和人类的功能障碍.
- 为了比较PAD患者的肌肉标志物和功能结果,与控制对象对重度酒精滥用和没有重度酒精滥用.
- 探索阿尔代脱酶2 (ALDH2) 在这些群体内的肌肉退化中的作用.
主要方法:
- 分析了来自三个组的胃半肌肉活检:严重酒精滥用PAD (PAD-AUD),没有严重酒精滥用PAD (PAD-LA) 的PAD和非PAD对照 (CON).
- 评估了氧化应激标志物 (4-HNE,蛋白质碳基,乙),线粒体功能和肌纤维形态.
- 评估下肢功能,包括步行距离和脚脚下 flexor 的强度.
主要成果:
- 与CON患者相比,PAD-LA患者表现出高氧化应激,线粒体病变和肌肉损伤.
- 在PAD患者中,像行走能力和肌肉力量这样的功能性结果减少了.
- 与PAD-LA患者相比,PAD-AUD患者的病理和功能障碍明显更严重.
- 在PAD-LA中,ALDH2水平上调,但在PAD-AUD肌肉中没有上调.
- 在PAD-LA中升高的ALDH2与减少的氧化应激相关,而在PAD-AUD中缺少ALDH2与增强的肌肉病理相吻合.
结论:
- 联合PAD和AUD导致骨肌肉功能障碍和病理的恶化.
- 在PAD-AUD中,ALDH2功能障碍似乎有助于肌肉退化.
- 在PAD中,ALDH2可以作为减轻氧化应激的潜在治疗标.
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