对比肉毒素和生物反疗法用于清醒布鲁克斯症:一个随机临床试验
Tatiana Ferreira Foscaldo1, Paulo Henrique Dos Santos Belo Junior1, Giselle Rodrigues Ribeiro1
1Department of Prosthodontics, Rio de Janeiro State University, Rio de Janeiro, Rio de Janeiro, Brazil.
BMC oral health
|November 11, 2025
概括
基于电肌图的生物反 (BIO) 在关节障碍患者中显著降低了清醒布鲁克西斯症行为. 毒素A型 (BTA) 没有显著改善,这表明BIO可能更适合用于管理 Bruxism行为.
科学领域:
- 牙科 牙科是指牙科的专业.
- 神经学 神经学
- 行为医学是一种行为医学.
背景情况:
- 在关节障碍 (TMD) 中,清醒布鲁克斯症 (AB) 的管理通常涉及行为疗法和注射.
- 基于电肌图的生物反 (BIO) 和甲型肉毒素 (BTA) 是AB的潜在治疗方法.
- 这项研究比较了BIO和BTA在患有AB的TMD患者的疗效.
研究的目的:
- 为了比较BIO和BTA在减少AB行为方面的有效性.
- 评估BIO和BTA对TMD患者疼痛强度和心理社会痛苦的影响.
- 确定在TMD中管理AB行为的首选治疗方法.
主要方法:
- 一个单中心,单盲,并行组随机临床试验与40名被诊断为TMD和AB的成年人进行.
- 参与者被随机分配到接受BIO或BTA干预.
- 评估包括口腔行为检查清单 (OBC),生态瞬间评估 (EMA),特征性疼痛强度 (CPI) 和心理社会问卷 (PHQ-9,PHQ-15,GAD-7) 在基线和1个月,3个月和6个月的随访.
主要成果:
- 生物组显示持续牙接触和EMA评估的全球AB行为显著减少.
- BTA组在AB行为中没有显著改善.
- 在任何随访点,在AB行为,疼痛强度或心理社会结果方面,在BIO和BTA组之间没有发现显著差异.
结论:
- 基于电肌图的生物反 (BIO) 在患有关节障碍的患者中显著降低了清醒布鲁克西斯症行为.
- 无论是BIO还是BTA干预都没有导致疼痛或心理社会结果的显著改善.
- 与TMD患者的BTA相比,BIO似乎是一个更有效的治疗方法来控制清醒的布鲁克斯主义行为.
更多相关视频
相关概念视频
Blind Procedures
12.8K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
12.8K
Blinding
3.8K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
3.8K


