膝关节骨关节炎中高患病率和多因素风险:系统性审查和元分析
Tian-Xin Chen1,2, Tong-Jie Yang2, Sheng Cheng1
1Dianjiang People's Hospital of Chongqing, Chongqing, 408300, China.
Journal of orthopaedic surgery and research
|November 11, 2025
概括
肉症是一种肌肉消耗的疾病,影响近25%的膝关节骨关节炎患者. 它的患病率与疾病的严重程度,糖尿病等并发症以及吸烟和不规则的体力活动等生活方式因素有关.
科学领域:
- 老年学是指老年学的学科.
- 整形外科 整形外科 整形外科
- 公共卫生 公共卫生
背景情况:
- 膝关节骨关节炎 (KOA) 是一种普遍存在的退行性关节疾病.
- 标志着肌肉质量和力量的损失的萨科佩尼亚,越来越多地被认为是各种慢性疾病的并发症.
研究的目的:
- 在被诊断患有膝关节骨关节炎 (KOA) 的患者中,系统地审查和元分析肉类的患病率和相关风险因素.
主要方法:
- 在多个数据库 (PubMed,科学网等) 进行了全面的文献搜索. 对于2000年1月至2025年6月期间发表的研究.
- 有资格的研究经过选,数据提取和质量评估.
- 使用Stata 17.0进行了元分析,以汇集流行数据并确定风险因素.
主要成果:
- 在35项研究中,在13528名KOA患者中,麻症的综合患病率为25.07%. 标本肥胖的流行率为12.06%.
- 观察到较高的麻症患病率与增加的KOA严重程度 (26.01%在Kellgren-Lawrence 4级),女性 (25.65%),和亚洲人群 (25.85%).
- 伴随性疾病 (骨质疏松症,糖尿病) 和生活方式因素 (酒精消费,吸烟,不规则的体力活动) 与肉类的患病率增加有关,特别是那些有不规则的体力活动的人中有35.20%.
结论:
- 在KOA患者中,sarcopenia和sarcopenic肥胖症非常普遍.
- 疾病的严重程度,性别,地理区域,并发症和生活方式因素在这个人群中与石症有显著的关联.
- 对于改善KOA患者的治疗结果和生活质量,例行评估和早期干预至关重要.
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