相关实验视频

Updated: Jan 11, 2026

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
11:57

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

483

阿尔茨海默病PSEN-2 N141I突变在人类iPSC衍生模型中显示出改变和剪切敏感的大脑内皮细胞类表型

Lily E Takeuchi1,2, Jennifer Lam3,4, Craig A Simmons5,6,7

  • 1Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada. lily.takeuchi@mail.utoronto.ca.

Acta neuropathologica communications
|November 11, 2025
PubMed
概括

缺乏脑血管剪切应激会使阿尔茨海默氏症 (AD) 内皮细胞功能障碍恶化. 微流体模型显示,施加剪切应力改善了流体输送障碍,并减少了阿尔茨海默病患者衍生的细胞中的单细胞粘附.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.血液-大脑屏障是什么?大脑内皮细胞是脑内皮细胞.低 perfusion 的意思就是低 perfusion.微流体学 微流体学干细胞是一种干细胞.

更多相关视频

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease09:33

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

8.3K
Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease06:52

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease

Published on: July 6, 2019

9.7K

相关概念视频

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.3K