在手术室内输入肥胖患者的输入管,有或没有袋口罩通风:随机多中心试验 (VENT 或不) 的研究方案
Souhaïl Znaïdi1, Romain Deransy2, Karim Asehnoune2,3
1Service d'Anesthésie-Réanimation en Chirurgie Cardiaque, CHU Nantes, Hôpital Guillaume Et René Laennec, Saint-Herblain, Bd Jacques Monod, 44093, France.
Trials
|November 11, 2025
概括
这项研究比较了标准输管与通风 (VENT策略) 与肥胖患者的快速序列输管 (NO VENT策略). 它旨在确定哪种方法可以更好地预防选择性手术中气管管道输液过程中的并发症.
科学领域:
- 麻醉学 麻醉学
- 关键护理医学 关键护理医学
- 外科手术患者管理
背景情况:
- 肥胖影响了近三分之二的欧洲成年人,在全身麻醉和输管治疗期间增加了风险.
- 由于吸入和脱的高风险,对于肥胖患者的最佳输管策略没有确立的共识.
- 接受选择性手术的严重肥胖患者需要仔细的麻醉管理,特别是在呼吸道手术方面.
研究的目的:
- 为了比较标准序列输管与通风 (VENT策略) 和快速序列输管 (NO VENT策略) 之间的输管相关并发症的发生率.
- 评估VENT策略在预防严重肥胖患者气管输管过程中的并发症方面的优势.
- 为肥胖手术患者的麻醉管理提供基于证据的指导.
主要方法:
- VENT OR NOT研究是一项前性,多中心,开放标签,随机化试验.
- 包括702名肥胖患者 (BMI≥35kg/m2) 需要气管管道输入用于选择性手术.
- 主要结局:诱导后10分钟内氧气脱 (<95%),输管失败,吸血/吐或严重低血压 (<80 mmHg缩血压) 的复合结果.
主要成果:
- 由于试验正在进行中,结果正在等待 (2023年9月至2025年9月的招生).
- 这项研究将提供有关两种输管策略相对安全性和有效性的数据.
- 这些发现将为管理麻醉期间肥胖患者的临床实践指南提供信息.
结论:
- VENT OR NOT试验是第一个随机对照试验,直接比较严重肥胖患者的这两种输管策略.
- 该研究将确定VENT策略 (带口罩通风的标准序列) 与NO VENT策略 (快速序列) 相比,是否可以减少输管相关的并发症.
- 预计这些结果将指导麻醉师优化这种高风险患者群体的呼吸道管理.
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