在老年双相情感障碍中,状体体积和认知功能之间的关联
Lisha Zhang1,2, Kun Qin3, Jianyu Li1,2
1Department of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
BMC psychiatry
|November 11, 2025
概括
胆管 (CP) 异常,包括更大的CP体积,与老年双相情感障碍 (BD) 认知能力下降有关. 这些发现表明,CP可能是改善BD认知的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 冠状腺 (CP) 涉及到衰老,认知和双极性障碍 (BD) 的发病.
- 在老年双相情绪障碍 (OABD) 中,CP与认知功能障碍之间的特定关系仍未得到研究.
研究的目的:
- 调查状体体积 (CPV) 和其他大脑体积测量在OABD患者认知障碍中的作用.
- 探索OABD中结构性大脑变化和认知功能之间的关联.
主要方法:
- 来自英国生物库的132名OABD患者和130名健康对照 (HC) 的分析.
- 检查CPV体积,灰质体积,白质体积,脑脊液体积和总脑体积 (TBV) 的不同.
- 相关性分析和k-means集群用于识别认知表型和相关的体积变化.
主要成果:
- 与HC相比,OABD患者的双边CPV和CSV显著增加,GMV和TBV减少.
- 在OABD中,认知功能与正确的CPV和CSV负相关,与GMV和TBV正相关.
- 双边CPV扩大与思维障碍特别相关,认知表现较差与CPV更高相关.
结论:
- 在OABD中,CP异常很突出,较大的CPV与较大的认知障碍有关.
- 在BD中,CP可能是缓解认知衰退和疾病进展的潜在治疗目标.
- 结构性大脑异常,包括GMV,CSV和TBV,与OABD的认知表现有关.
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