基于抗体的治疗方法的技术进步用于治疗疾病
Ruei-Min Lu1, Hsiao-Ling Chiang1, Joyce Pei-Yi Yuan1
1Biomedical Translation Research Center, Academia Sinica, Taipei, 11571, Taiwan.
Journal of biomedical science
|November 11, 2025
概括
治疗性抗体工程已经迅速发展,导致新的药物格式,如抗体-药物合物和双特异性抗体. 交付和人工智能的创新正在加速各种疾病的发现和临床转化.
科学领域:
- 生物技术是生物技术.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 单克隆抗体 (mAbs) 是瘤学,免疫学和神经学中至关重要的治疗方法.
- 自1975年以来的技术进化改善了mAb的特异性,功效和安全性.
- 截至2025年8月,FDA批准了144个mAbs,有1516个候选药物在临床开发中.
研究的目的:
- 提供对治疗性抗体开发近期进展的全面审查.
- 突出新兴的抗体格式,输送策略和发现平台.
- 讨论人工智能,工程和信息学在抗体医学中的整合.
主要方法:
- 对抗体工程和发现方面的技术创新进行审查.
- 分析新的治疗方式,如ADC,bsAbs和CAR-T疗法.
- 检查先进的传递系统 (mRNA-LNP) 和计算工具 (AI/ML,NGS).
主要成果:
- 美国食品和药物管理局批准的mAbs和临床管道候选药物的显著增长.
- 新型抗体格式和精确传递策略的出现.
- 通过AI/ML和NGS集成加速抗体设计和发现.
- 全球抗体疗法市场在2024年将超过2670亿美元.
结论:
- 抗体工程继续推动跨多种疾病领域的治疗创新.
- 多种技术的整合对于有效的抗体设计和临床转化至关重要.
- 该领域已准备好对未满足的医疗需求和全球卫生优先事项产生重大影响.
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