肺癌查:对过度诊断及其影响的系统审查
Fiorella Karina Fernández-Sáenz1,2,3, Laura de la Torre-Perez1,2, David R Baldwin4
1Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.
Molecular oncology
|November 12, 2025
概括
低剂量计算机断层扫描 (LDCT) 查肺癌可能会导致轻微的过度诊断. 经济影响是额外的社会负担,尽管与胸部X射线相比,过度诊断的程度较低.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 卫生经济学 卫生经济学
背景情况:
- 低剂量计算机断层扫描 (LDCT) 广泛用于高风险个体的肺癌查.
- 量化过度诊断及其相关的危害和成本对于知情的临床实践至关重要.
研究的目的:
- 评估LDCT对高风险人群的查导致的肺癌过度诊断的规模,危害和经济影响.
主要方法:
- 一个系统的审查和八个随机试验的元分析,涉及84,660名参与者.
- 较量LDCT查与没有查以及与胸部X射线 (CXR) 相比.
主要成果:
- 与没有查 (RR 1.05) 和CXR (RR 1.01) 相比,LDCT查可能会略微增加过度诊断.
- 过度诊断的癌症占检测到的肺癌的7% (vs没有查) 和1% (vsCXR).
- 与没有查相比,LDCT查额外产生了2,026,422欧元的社会成本,每10万个被查的人.
结论:
- 使用LDCT查过度诊断的程度似乎很低,特别是与CXR相比.
- 虽然LDCT查有助于早期检测,但潜在的过度诊断和经济后果需要仔细考虑.
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