基于冠状动脉的冠状动脉疾病多基因评分的差异性表现,与艾滋病毒感染者和无艾滋病毒感染者之间存在差异
Genevieve Wojcik1, Marios Arvanitis2, Sabina Haberlen1
1Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA.
Journal of the American Heart Association
|November 12, 2025
概括
冠状动脉疾病的多原风险评分 (PRSCAD) 在预测冠状动脉的表现较低,与没有艾滋病毒的人 (PWOH) 相比,与艾滋病毒感染者 (PLWH) 相比. 对于PLWH中准确的风险预测模型,需要进一步的研究.
科学领域:
- 心血管疾病的研究研究.
- 遗传学和个性化医学
- 艾滋病毒/艾滋病研究研究
背景情况:
- 艾滋病毒感染者面临着冠状动脉疾病 (CAD) 的更高风险.
- 在艾滋病毒感染者 (PLWH) 中,多基因风险评分对CAD (PRSCAD) 的有效性尚不清楚.
- 冠状动脉 (CAC) 作为亚临床动脉样硬化的关键指标.
研究的目的:
- 评估PRSCAD在评估PLWH中CAC的表现,与没有艾滋病毒的人 (PWOH) 相比.
- 为了确定PRSCAD是否与现有的风险计算器相结合,可以改善CAD风险预测.
主要方法:
- 在多中心艾滋病队列研究 (MACS) 中,对1071名男性进行了PRSCAD,按艾滋病毒状况,种族和遗传血统分层.
- 使用CAC的Agatston分数 (AS) 来评估性能,评估调整后的R2和曲线下的面积 (AUC).
- 模型被独立比较,并与聚合队列方程 (PCE) 共同比较.
主要成果:
- 与基线相比,PRSCAD显著改善了非西班牙裔白人男性的CAC预测,但与PCE相加时没有.
- 在PLWH的表现低于PWOH,特别是在区分高CAC和没有CAC时.
- 与白人男性相比,PRSCAD在黑人男性中表现较差,PLWH的准确性降低.
结论:
- 与PWOH男性相比,PRSCAD在PLWH中对CAC的预测性能较低.
- 目前的PRSCAD模型需要进一步细化,以便在PLWH中有效的临床实用性.
- 针对性风险预测模型的开发对于改善艾滋病毒感染者的心血管健康结果至关重要.
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