通过植物性饮食预防和逆转高血压诱导的冠状动脉微血管功能障碍
Rami S Najjar1,2, Nedumangalam Hekmatyar3, Yanling Wang1
1Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences Georgia State University Atlanta GA USA.
Journal of the American Heart Association
|November 12, 2025
概括
植物性饮食 (PBD) 可以预防和逆转冠状动脉微血管功能障碍 (CMD) 在高血压的老鼠. 这种饮食干预改善了内皮和血管光滑肌细胞功能,为人类心血管健康提供了希望.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 血管生物学 血管生物学
背景情况:
- 冠状动脉微血管功能障碍 (CMD) 是心血管不良结果的重要危险因素.
- 冠状动脉疾病源于内皮和血管光滑肌细胞 (VSMC) 功能受损.
- 高血压是CMD的一个关键因素.
研究的目的:
- 研究植物性饮食 (PBD) 在高血压大鼠模型中减轻CMD的潜力.
- 在高血压的背景下,评估PBD对内皮和VSMC功能的影响.
主要方法:
- 比较Wistar-Kyoto和自发高血压大鼠 (SHRs),从4周大开始食对照或PBD.
- 评估CMD使用心声回声学 (冠状动脉流量储备) 和心脏MRI.
- 评估内皮和VSMC功能,心脏氧化应激,炎症和纤维化.
- 通过16S测序和抗生素治疗探索肠道微生物群的作用.
主要成果:
- SHRs显示内皮细胞和VSMC功能障碍.
- 一个PBD没有降低血压,但有效地预防和逆转CMD.
- 消费PBD改善了内皮氧化合成酶功能和氧化介导的VSMC信号.
- 在SHR中,PBD摄入量减少了心脏氧化应激,炎症和纤维化.
结论:
- 一个PBD是有效的预防和逆转CMD在高血压的老鼠,独立于其对高血压的影响.
- 这些好处归因于改善了内皮和VSMC功能.
- 这些发现支持需要进行临床试验,评估人类CMD的PBD.
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