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升高的WBC/HDL比率预测中风后的功能预后

Haobo Wang1, Xiangqi Kong1, Xinyue Yuan1

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白细胞与高密度脂蛋白胆固醇 (WBC/HDL) 的比率预测急性缺血性中风 (AIS) 患者的结果不佳. 较高的WBC/HDL比率表明,中风后90天的不良功能结果的风险更大.

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科学领域:

  • 神经学 神经学
  • 生物标志物 生物标志物
  • 炎症 炎症是一种炎症.

背景情况:

  • 炎症和脂质代谢是急性缺血性中风 (AIS) 病原和结果的关键.
  • 白细胞与高密度脂蛋白胆固醇 (WBC/HDL) 的比例是系统性炎症和抗炎能力的新生物标志物.

研究的目的:

  • 评估WBC/HDL比率在预测AIS患者90天功能结果中的预后价值.

主要方法:

  • 追溯地招募了837名AIS患者.
  • 在入院时计算基线WBC/HDL比率.
  • 评估90天的功能结果,使用修改的兰金尺度 (>2表示不良结果).
  • 使用后勤回归,限制立方线 (RCS) 曲线和子组分析来评估关联.

主要成果:

  • 较高的WBC/HDL比率与功能表现不佳有显著关联.
  • 在对共变量进行调整后,这种关联仍然很强 (调整后的OR:1.2589;p=0.0001).
  • 最高的WBC/HDL三位数与最低的三位数相比,差异性结果的风险几乎是两倍,通过RCS分析观察到线性剂量反应关系.
  • 亚组分析证实了不同患者人口统计学和疾病之间的一致关联.

结论:

  • 在AIS中,WBC/HDL比率独立预测90天的功能结果.
  • 它作为AIS患者早期风险分层的实用生物标志物.