升高的WBC/HDL比率预测中风后的功能预后
Haobo Wang1, Xiangqi Kong1, Xinyue Yuan1
1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.
Brain and behavior
|November 12, 2025
概括
白细胞与高密度脂蛋白胆固醇 (WBC/HDL) 的比率预测急性缺血性中风 (AIS) 患者的结果不佳. 较高的WBC/HDL比率表明,中风后90天的不良功能结果的风险更大.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 炎症 炎症是一种炎症.
背景情况:
- 炎症和脂质代谢是急性缺血性中风 (AIS) 病原和结果的关键.
- 白细胞与高密度脂蛋白胆固醇 (WBC/HDL) 的比例是系统性炎症和抗炎能力的新生物标志物.
研究的目的:
- 评估WBC/HDL比率在预测AIS患者90天功能结果中的预后价值.
主要方法:
- 追溯地招募了837名AIS患者.
- 在入院时计算基线WBC/HDL比率.
- 评估90天的功能结果,使用修改的兰金尺度 (>2表示不良结果).
- 使用后勤回归,限制立方线 (RCS) 曲线和子组分析来评估关联.
主要成果:
- 较高的WBC/HDL比率与功能表现不佳有显著关联.
- 在对共变量进行调整后,这种关联仍然很强 (调整后的OR:1.2589;p=0.0001).
- 最高的WBC/HDL三位数与最低的三位数相比,差异性结果的风险几乎是两倍,通过RCS分析观察到线性剂量反应关系.
- 亚组分析证实了不同患者人口统计学和疾病之间的一致关联.
结论:
- 在AIS中,WBC/HDL比率独立预测90天的功能结果.
- 它作为AIS患者早期风险分层的实用生物标志物.
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