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炎症性肠病和神经精神疾病之间的因果关系:双向孟德尔随机化研究

Jiawei Lei¹, Liping Gong¹, Shan Wei¹

¹Department of Gastrointestinal and Burn Surgery, The First Affiliated Hospital of Hunan Traditional Chinese Medical College (Hunan Provincial Directly Affiliated Hospital of Traditional Chinese Medicine), Zhuzhou, China.

Brain and behavior

|November 12, 2025

概括

这项研究表明,炎症性肠病 (IBD) 和其亚型可能会对主要抑郁症和精神分裂症产生因果关系. 这些发现突显了IBD和神经精神疾病之间的双向联系,支持肠-大脑轴.

科学领域:

遗传学和流行病学
神经科学是一个神经科学.
胃肠病学胃肠病学

背景情况:

观察性研究表明,炎症性肠病 (IBD) 和神经精神疾病之间存在联系.
这种关联的因果性仍未确定.

研究的目的:

通过双向两样本孟德尔随机化 (MR) 方法,研究IBD和七种主要神经精神疾病之间的潜在因果关系.
探索IBD亚型,克罗恩病 (CD) 和性结肠炎 (UC) 以及神经精神疾病之间的潜在因果关系.

主要方法:

使用全基因组关联研究 (GWAS) 来自欧洲祖先的总结统计数据.
对IBD (包括CD和UC) 和主要抑郁障碍 (MDD),双相情感障碍 (BD),精神分裂症 (SCZ),阿尔茨海默病 (AD),帕金森病 (PD),多发性硬化症 (MS) 和肌缩侧面硬化症 (ALS) 进行了双向两样本MR分析.
进行了敏感性分析,以确保调查结果的可靠性.

主要成果:

确定IBD和CD对MDD和SCZ的潜在积极因果影响.
在SCZ和IBD和UC风险增加之间发现了积极的关联.
观察到IBD,UC和MS之间的双向正相关性,CD也对MS产生了积极的因果作用.
没有证据表明MDD,BD,AD,PD或ALS对IBD或UC的因果作用.

结论:

结果支持IBD (CD和UC) 和几个神经精神疾病之间的潜在因果关系.
这些发现强化了肠-大脑轴的概念.
增强对IBD的肠外表现和IBD患者神经精神方面的理解.

关键词:

门德尔的随机化炎症性肠病是一种炎症性肠病.神经精神疾病:神经精神疾病.

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