基于质子梯度的pH响应纳米材料在瘤微环境中的设计和应用
Jianjun Jiang1, Limin Jin1, Zengkai Zhao1
1State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, PR China. fzli@bme.pumc.edu.cn.
Nanoscale
|November 12, 2025
概括
响应pH的纳米粒子通过响应酸度为瘤提供向的药物输送. 未来的纳米医学可以利用质子梯度进行主动向,提高癌症治疗效率.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 瘤微环境 (TME) 具有独特的pH值,对癌症的进展至关重要.
- 响应pH的纳米粒子利用质子化或键裂解来释放药物.
- 现有的纳米平台包括基于脂质的纳米颗粒 (LNP),和金属有机框架 (MOF).
研究的目的:
- 审查用于TME药物输送的pH响应纳米材料的最新进展.
- 突出各种纳米载体中的分子策略,如半孔纳米粒子 (MSN) 和脂质体.
- 确定pH响应纳米医学的局限性和未来方向.
主要方法:
- 对pH响应纳米粒子设计和应用的文献综述.
- 强调特定纳米材料类型 (MSN,脂质体,LNP,MOF等) 中的分子策略. ) 的情况.
- 分析当前的挑战,并提出未来的研究途径.
主要成果:
- 已经开发出多种响应pH的纳米平台,使用不同的机制.
- 详细介绍了中孔纳米颗粒 (MSN),脂质体和基于脂质的纳米颗粒 (LNP) 的进展.
- 局限性包括瘤选择性差,未定义的pH值,以及依赖于简单模型.
结论:
- 目前的pH响应纳米粒子需要提高瘤选择性和更好的值定义.
- ортотоп瘤模型对于准确模仿TME至关重要.
- 未来的研究应该探索使用质子梯度作为增强纳米医学的能源的积极准.
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