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评估神经肌肉电刺激的有效频率,以防止关节收缩在老鼠模型中

Yuta Sato¹, Takeya Ono¹, Yuta Hirose²

¹Department of Health and Welfare, Prefectural University of Hiroshima, Mihara, JPN.

|November 12, 2025

概括

较低频率的神经肌肉电刺激 (NMES),诱导人造抽肌肉收缩,在预防关节收缩方面比较高频率导致缩更有效.

科学领域:

生物医学工程生物医学工程
康复科学康复科学康复科学
整形外科整形外科整形外科

背景情况:

不承重的后肢关节固定导致严重的关节收缩.
神经肌肉电刺激 (NMES) 显示出预防关节收缩的潜力.
预防关节收缩的最佳NMES频率仍然不清楚.

研究的目的:

调查NMES的有效频率,以防止关节收缩.
为了比较不同NMES频率 (抽和缩) 对关节收缩的影响.

主要方法:

60只老鼠接受了一周的右脚关节固定和后肢悬浮.
鼠被分为四组:没有NMES,1 Hz ES,10 Hz ES (抽) 和50 Hz ES ().
测量了脚背部屈曲角度,足底肌的伸展性和原蛋白含量.

主要成果:

与没有NMES相比,NMES在1-50 Hz的频率减少了脚背曲角度和足底肌伸展性的减少.
较低的NMES频率 (1 Hz和10 Hz,诱导抽) 比较高的频率 (50 Hz,诱导缩) 更有效.
两组之间没有观察到I型和III型原蛋白含量的显著差异.

结论:

在预防关节收缩方面,NMES诱导的人工抽肌肉收缩比缩更有效.
建议使用较低的NMES频率,以防止与关节固定相关的关节收缩.

关键词:

联合承包商是指共同承包商.关节固定方式关节固定方式肌肉肌肉肌肉肌肉肌肉神经肌肉电刺激是一种神经肌肉电刺激.没有负重的不负重的.紧张的收缩紧张的收缩抽收缩抽收缩

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相关概念视频

Muscle Stimulation Frequency

Muscle Stimulation Frequency

The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...