与代谢功能障碍相关的脂肪肝和2型糖尿病:病理生理学联系,流行病学趋势和临床影响
Mohammad Sarif Mohiuddin1, Noushin Tabassum Neha2, Jawad Ul Karim Mahir2
1Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY, United States.
Frontiers in endocrinology
|November 12, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和2型糖尿病 (T2DM) 分享了类似胰岛素抵抗的共同途径. 早期查和生活方式的改变是关键,新的治疗方法显示出希望.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是与T2DM等代谢障碍相关的日益严重的公共卫生问题.
- 超过60%的T2DM患者表现出肝脏肥胖症,突出显示了MASLD和T2DM之间的密切关联.
- 共同的病理生理机制包括胰岛素耐药性,脂质生成,炎症和肠道微生物群的改变.
研究的目的:
- 审查MASLD和T2DM之间的双向关系.
- 讨论共享的病理生理机制.
- 突出早期查和多学科管理的需要.
主要方法:
- 对研究的文献综述,研究了MASLD和T2DM之间的联系.
- 分析共享的分子和代谢途径.
- 讨论当前和潜在的治疗策略.
主要成果:
- MASLD和T2DM有共同的途径,包括胰岛素抵抗,炎症和改变的肠道微生物群.
- 肥胖和代谢综合征是这两种疾病的危险因素.
- 生活方式的改变是主要的治疗方法,但针对胰岛素信号和脂质代谢的药理干预正在出现.
结论:
- MASLD在T2DM病变发生过程中发挥着重要作用,需要在高风险人群中进行早期检测.
- 标准化诊断标准和开发有效的治疗方法仍然是一个挑战.
- 涉及肝病学,内分泌学和公共卫生的多学科方法对于管理这种全球流行病至关重要.
关键词:
亚迪波基因 (Adipokine) 是一种可靠的药物.肝脏肥胖症 肝脏肥胖症这是一种炎症炎症炎症炎症.胰岛素耐药性 (IR) 是一种脂肪毒性 脂肪毒性 脂肪毒性与代谢功能障碍相关的脂肪肝疾病 (MASLD)非酒精性脂肪肝疾病 (NAFLD) 是一种非酒精性脂肪肝疾病.二型糖尿病 (T2DM) 是一种糖尿病.更多相关视频
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