铜摄入量与慢性病/糖尿病病之间的关系:来自NHANES数据 (2011-2018) 的见解
Shasha Hu1, Xiao Tian2, Zhenzhen Wang3
1Department of Nephrology, Zibo Central Hospital, Zibo, China.
Frontiers in endocrinology
|November 12, 2025
概括
较高的铜摄入量显示出对慢性病 (CKD) 和糖尿病病 (DKD) 的保护作用. 这种反向关联在研究人口中的各种子组中得到了一致的观察.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 饮食中的铜摄入量与病,特别是慢性病 (CKD) 和糖尿病病 (DKD) 之间的关系仍然不完全理解.
- 研究这种关联对于理解影响脏健康的饮食因素至关重要.
研究的目的:
- 检查铜消费与CKD和DKD患病率之间的关联.
- 探索铜摄入量与病结果之间的潜在非线性关系.
主要方法:
- 利用了2011-2018年国家健康和营养检查调查 (NHANES) 的16,948名参与者的数据.
- 使用加权t测试和千平方测试进行变量比较,以及多变量逻辑回归来建模关联.
- 应用限制立方线 (RCS) 分析,以调查铜摄入量与病之间的非线性关联.
主要成果:
- 在铜摄入量和CKD (OR > 0.80) 和DKD (OR > 0.5) 之间发现了显著的负相关性.
- 这种保护性关联在所有被检查的人口子组中都存在.
- RCS分析表明非线性,反向的关联,特别是在较低的摄入水平 (例如,OR = 0.51的CKD摄入量≤1.47毫克;OR = 0.40的DKD摄入量≤0.98毫克).
结论:
- 饮食中的铜摄入量与CKD和DKD有显著和反向的相关性.
- 这些发现表明,在病的背景下,充足的铜消费可能起着保护作用.
- 进一步研究最佳的铜摄入水平,以改善脏健康是有必要的.
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