相关实验视频

Updated: Jan 11, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

胆道癌系统治疗的最新进展:一篇文献综述

Muhammad Masroor Hussain^1,2, Sana Qammar³, Ju-Mei Wang^1,2

¹Division of Biliary Tract Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.

Journal of gastrointestinal oncology

|November 12, 2025

概括

胆道癌 (BTC) 的全身疗法正在发展,有针对性的治疗和免疫疗法显示出希望. 以分子生物标志物为指导的个性化医学是改善这些侵袭性恶性瘤的生存率的关键.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
药理学药理学是指药理学的学科.

背景情况:

胆道癌 (BTC) 是一种罕见的,具有不良预后的侵袭性恶性瘤.
由于耐药性和异质性,传统化疗 (gemcitabine和cisplatin) 的疗效有限.
迫切需要新的全身疗法来改善患者的治疗结果.

研究的目的:

审查BTC系统治疗的最新进展.
突出分子导向治疗和生物标志物的作用.
总结新兴的化疗,向治疗和免疫治疗策略.

主要方法:

在PubMed,EMBASE,谷歌学者和科克兰图书馆 (2010-2024) 的综合文献搜索.
包括同行评审的临床试验,元分析和会议摘要.
专注于新兴的治疗方法,分子点和生物标志物集成.

主要成果:

识别可操作的变化 (例如,FGFR2融合,IDH1/2突变),使得有针对性的治疗成为可能.
免疫检查点抑制剂 (ICI) 与化疗相结合,显示出生存益处 (TOPAZ-1,KEYNOTE-966).
新的二线选择包括纳米脂质体内氨基酸和双ICI组合.

结论:

针对BTC的全身疗法正在转向精确瘤学和免疫疗法.
基于分子特征的个性化治疗对于改善结果至关重要.
未来的研究应该集中在生物标志物识别和耐药性机制上.

关键词:

胆道癌 (BTC) 是一种胆道癌.胆瘤是一种胆瘤.免疫检查点抑制剂 (ICI)系统性治疗是全身疗法.有针对性的治疗.

更多相关视频

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...