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由于吸烟和代谢因素导致的口腔微生物变化,导致食道状细胞癌的发生

Kyoungwon Jung¹, Minjae Joo², Kwangwoo Nam³

¹Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea.

Journal of gastrointestinal oncology

|November 12, 2025

概括

特定的口腔细菌,如Haemophilus parainfluenzae,Veillonella dispar和Streptococcus infantis在食道状细胞癌 (ESCC) 患者的丰度发生变化,与临床和代谢因素有关.

科学领域:

微生物组研究的研究.
在瘤学瘤学.
代谢研究的研究.

背景情况:

了解临床因素对微生物特征的影响至关重要,但在食道状细胞癌 (ESCC) 中还没有充分研究.
本研究调查了ESCC患者和健康对照人群之间的口腔微生物组差异,考虑了临床和代谢变量.

研究的目的:

与健康个体相比,分析ESCC患者的口腔微生物组变异.
探索临床和代谢因素如何影响ESCC的口腔微生物组成.

主要方法:

从ESCC患者和对照组中采集了口腔抽样和临床数据 (年龄,BMI,吸烟,脂质,内镜检测结果).
微生物群分析涉及测序和标本丰度比较.
亚组分析检查了临床因素对微生物多样性和社区结构的影响.

主要成果:

在ESCC患者和对照人群之间,口腔微生物群多样性没有总体差异.
在较年轻,低LDL ESCC患者中,Hemophilus parainfluenzae的丰度下降.
在ESCC患者中,Veillonella dispar和Streptococcus infantis的丰度因年龄,LDL水平和吸烟状况而变化.

结论:

特定的口腔微生物,包括H. parainfluenzae,V. dispar和S. infantis,可能充当ESCC的潜在生物标志物.
这些潜在的生物标志物受到代谢因素的影响,这突显了它们在ESCC病原和诊断中的相关性.

关键词:

食道癌是食道癌的一个类型.代谢因素是代谢因素.口腔微生物组是口腔的微生物组.吸烟是为了吸烟.

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