母亲喘和肺功能,儿童喘和生长:MAESTRO-Child研究
Emma Caffrey Osvald1,2, Cecilia Lundholm1, Bronwyn K Brew1,3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ERJ open research
|November 12, 2025
概括
母亲喘和过敏性喘增加了儿童喘的风险. 然而,在怀孕期间改善母亲的肺功能可能会降低这种风险. 怀孕期间母亲的健康状况没有影响儿童的成长.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 肺部病理学 肺部病理学
背景情况:
- 母婴喘与不良儿童健康结果有关,包括儿童喘和低出生体重.
- 了解母亲呼吸系统健康对后代的影响对于预防策略至关重要.
研究的目的:
- 调查母亲喘,过敏性喘和肺功能与儿童喘和生长之间的关联.
- 为了确定母亲的呼吸系统健康是否会影响儿童喘的发展.
主要方法:
- 一个瑞典怀孕队列 (MAESTRO) 与儿童和国家健康数据 (529对母婴对) 相联系.
- 孕妇肺功能 (FEV1,FVC,FEV1/FVC,支气管扩展剂反应) 在怀孕期间测量.
- 儿童喘和成长通过问卷和登记数据进行评估;使用特定标准定义母亲喘和过敏喘.
主要成果:
- 母亲过敏性喘显著增加了6岁儿童喘的风险 (adjRR 2.07).
- 在母体中,更高的支气管扩展前和后FEV1与儿童喘风险降低有关 (adjRR分别为0.50和0.45).
- 在母亲的肺功能参数 (FVC,FEV1/FVC,支气管扩展剂反应) 和儿童生长之间没有发现显著的关联.
结论:
- 孕产妇的喘,特别是过敏性喘,是儿童喘的重要危险因素.
- 在怀孕期间改善母亲的肺功能可能会对儿童喘发育产生保护作用.
- 母亲喘和肺功能与后代生长没有统计学上显著的关联.
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