发炎的口服抗生素和囊炎的口服抗生素之间的共同耐药性 - - 将升级抗生素图模型应用于当地社区数据
Philip Williams1,2,3, Edward Barton2,3, Ranjeet Bhamber4
1School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, Bristol, UK.
JAC-antimicrobial resistance
|November 12, 2025
概括
据推测,对常见囊炎抗生素的耐药性显著影响了炎治疗选择. 升级抗生素图有助于指导抗生素选择,以获得更好的患者结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 尿路感染 (UTI) 很常见,囊炎和炎炎需要不同的抗生素治疗方法.
- 了解对第一线囊炎抗生素的耐药性和对炎抗生素的耐药性之间的关系对于有效治疗至关重要.
研究的目的:
- 评估假定对囊炎的第一线抗生素的耐药性如何影响用于发炎的抗生素的耐药性.
- 通过升级抗生素图谱模型,为皮叶龙炎的实证抗生素处方提供信息.
主要方法:
- 贝叶斯模型应用于来自13万多个大肠杆菌尿液分离物 (2019-2023) 的敏感性数据.
- 该模型估计了基于对囊炎抗生素的假定耐药性的抗生素耐药率.
- 分析包括基于年龄和复发性尿路感染史的患者子组.
主要成果:
- 假定对囊炎抗生素的耐药性明显影响对炎抗生素的耐药性.
- 如果假定对Pivmecillinam的耐药性 (预测耐药性>50%),则应避免使用阿莫西西林/克拉夫兰酸治疗发炎.
- 最佳的炎症抗生素选择取决于年龄和感染史,当假定耐黄或trimethoprim的耐药性时.
结论:
- 一个由贝叶斯模型告知的升级抗生素图是实证炎抗生素处方的宝贵工具.
- 这种方法提供了局部耐药性估计,并将抗生素选择与不确定性测量进行比较.
- 它支持对治疗白炎的知情临床决策.
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