在死后的移植后的捐赠者衍生的PLA2R阳性膜性病
Bastian Robinson Baarz1, Jan Jochims2, Nadine Unterwalder3
1Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Clinical kidney journal
|November 12, 2025
概括
捐赠者衍生的脂酶A2受体阳性膜性脏病 (MN) 是罕见的. 来自未被诊断为MN的捐赠者的脏可以导致可接受的移植结果,即使是最初的移植功能障碍.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 淋巴细胞疾病 淋巴细胞疾病
背景情况:
- 捐赠者衍生的球体疾病不常见,并且很难在移植后诊断.
- 脂酶A2受体 (PLA2R) 阳性膜性脏病 (MN) 是一种主要的球膜性疾病.
研究的目的:
- 报告从已故捐赠者的两个脏移植接受者之前未被诊断的PLA2R阳性MN.
- 评估从未诊断到的MN的捐赠者移植的结果.
主要方法:
- 两名脏移植接受者的案例报告.
- 对移植功能,蛋白尿和血清抗PLA2R抗体的分析.
- 对抗PLA2R抗体进行回顾性供体检测.
主要成果:
- 两位接受者都从未诊断出PLA2R阳性MN的捐赠者获得了脏.
- 接收者1有延迟的移植功能和粗蛋白尿,活检证实PLA2R阳性MN.
- 接收者2具有即时的移植功能和暂时的白色素尿.
- 追溯的供体检测证实了抗PLA2R抗体,这表明来自供体的MN.
- 两位接受者都表现出改善或稳定的移植功能与标准免疫抑制.
结论:
- 来自未被诊断为PLA2R阳性MN的捐赠者的脏可以导致可接受的移植结果.
- 在移植后球体疾病的情况下,应考虑捐赠者衍生的MN.
- 标准免疫抑制可能足以管理来自供体的MN.
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