瘤微环境中的IFN-:癌症进展和治疗中的双重作用
Jiahui Cui1, Yi Zhang1,2,3,4,5, Li Yang1,2,3,4
1Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
EXCLI journal
|November 12, 2025
概括
干扰素- (IFN-γ) 在癌症免疫中起着双重作用,促进瘤回归,但也可能导致治疗耐药性. 精确的调制是有效的IFN-γ癌症免疫治疗的关键.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 干扰素- (IFN-γ) 是抗瘤免疫的一个关键细胞因子.
- 它的免疫刺激,抗增殖和前性作用表明在癌症免疫治疗中具有潜力.
研究的目的:
- 突出IFN-γ在癌症发展和治疗期间在瘤微环境中的双重作用.
- 讨论利用IFN-γ在癌症治疗中的挑战和机会.
主要方法:
- 关于IFN-γ在瘤微环境中的机制现有文献的综述.
- 分析IFN-γ对免疫细胞,抗原呈现和血管生成的影响.
- 检查IFN-γ诱导的免疫逃避机制,包括免疫检查点上调和T细胞耗尽.
主要成果:
- IFN-γ 增强抗原呈现,细胞毒性T细胞和NK细胞活性,并抑制血管生成,促进瘤回归.
- 长时间的IFN-γ暴露可能导致免疫检查点上调 (例如PD-L1),T细胞疲劳和调控性T细胞招募,导致治疗耐药性.
- 临床研究中不一致的结果凸显了IFN-γ作用的复杂性.
结论:
- IFN-γ在癌症中表现出复杂的双重作用,同时作为抗瘤剂和治疗耐药性的调解剂.
- 了解特定的微环境环境对于优化基于IFN-γ的癌症疗法至关重要.
- 精确调节IFN-γ是必要的,以最大限度地提高其治疗效益,同时最大限度地减少突瘤的影响,以获得成功的临床转化.
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