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Updated: Jun 11, 2026

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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案例报告:EGFR突变的大细胞神经内分泌癌的演变和向治疗

Li Jiang1, Xiaowen Yao1, Xiuyu Cai1

  • 1Department of Traditional Chinese Medicine, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Frontiers in oncology
|November 12, 2025
PubMed
概括

这种病例研究显示了一个患有EGFR突变肺大细胞神经内分泌癌 (LCNEC) 的患者,该病例转化为小细胞肺癌 (SCLC). 通过重复的分子分析和重新评估指导治疗,实现了48个月的整体生存期.

关键词:
欧洲农业基金会 (EGFR) 是一个基金.欧洲农业基金外区21 L858RR氨酸激酶抑制剂 (TKI) 是一种氨酸激酶抑制剂.大细胞神经内分泌癌 (LCNEC)肺癌是一种肺癌.

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