心力衰竭中的神经网络连接异常与减少和轻度射出分数患者:一个独立的组件和动态功能网络连接分析
Qian Gao1,2, Junyan Wen1, Yi Lu2
1Department of Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Frontiers in neurology
|November 12, 2025
概括
心力衰竭患者表现出大脑连接的改变,影响认知功能. 减少在特定大脑状态中的停留时间与射出分数和认知分数相关,这表明HF管理的潜在成像标记.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 医疗成像医学成像
背景情况:
- 心力衰竭 (HF) 与认知和情感障碍有关.
- 在HF中这些并发症背后的神经机制尚未完全理解.
研究的目的:
- 研究大规模大脑网络中的静态和动态功能连接 (FC) 变化.
- 将心力衰竭中的大脑网络变化与减少 (HFrEF) 和中等范围 (HFmrEF) 喷射分数患者与健康对照 (HC) 进行比较.
主要方法:
- 利用独立组件分析 (ICA) 来识别静止状态网络 (RSN) 和FC差异.
- 使用移动窗口分析和k-means集群用于动态功能网络连接 (dFNC) 和状态识别.
- 分析了连接状态的时间特征,并将它们与临床措施相关联.
主要成果:
- 高压患者在注意力和前对对联网络中表现出降低的FC,在突出网络中增加了FC.
- dFNC揭示了五种连接状态;HF患者在感官认知隔离状态中的停留时间更短.
- 这种状态的停留时间与左心室喷射率 (LVEF) 和迷你精神状态检查 (MMSE) 得分呈正相关.
结论:
- 在HF患者中,静态和动态连接的破坏可能解释认知和情感脆弱性.
- 面对面,注意力和突出网络的变化是关键发现.
- 这些连接变化为早期高频风险监测和管理提供了潜在的成像标记.
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