影响早期多发性硬化症患者健康行为变化的因素:多中心随机受控POWER@MS1试验的过程评估
Barbara von Glasenapp1, Nicole Krause1, Carlotta Derad2
1Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Frontiers in neurology
|November 12, 2025
概括
数字生活方式应用程序 (levidex) 支持多发性硬化症 (pwMS) 患者采取更健康的行为,与对照组相比,饮食,体力活动和压力管理显著改善.
科学领域:
- 数字健康干预措施 数字健康干预措施
- 生活方式医学生活方式医学
- 多发性硬化症管理管理
背景情况:
- 健康行为变化 (体力活动,饮食,睡眠,压力管理) 是多发性硬化症 (MS) 的关键预后风险修饰因素.
- 一个个性化的数字生活方式管理应用程序,levidex,被开发来帮助MS (pwMS) 患者管理他们的诊断和采用更健康的行为.
- 在随机对照试验 (RCT) POWER@MS1.1.中,Levidex应用与积极的精神教育控制计划 (dexilev) 相比进行了评估.
研究的目的:
- 评估POWER@MS1试验,重点关注研究的过程和组织方面.
- 识别影响pwMS行为变化的上下文因素.
- 评估pwMS和医疗保健专业人员 (HCP) 对干预和研究设计的看法.
主要方法:
- 采用混合方法方法,将定量问卷数据和定性半结构面试数据结合起来.
- 在RCT期间,从234名 pwMS和91名HCP收集了定量数据.
- 在RCT后,从15名医疗保健工作者和16名pwMS收集了定性数据,采用最大变异采样进行选择,并对两种数据类型进行了主题分析.
主要成果:
- 3个月后,Levidex组与行为变化达成的协议显著增加 (6.65对5.23,p < 0.001),报告了饮食,体力活动和压力管理的改善.
- PwMS发现levidex中的基于证据的信息,冥想指导和自我监测工具特别有帮助.
- pwMS和HCP都认为健康的生活方式对MS治疗至关重要,认为levidex是标准护理的宝贵补充,尽管需要额外的个人咨询.
结论:
- 健康行为改变被认为是多发性硬化症治疗的关键组成部分.
- 像levidex这样的数字应用程序被认为是促进 pwMS 中必要的行为改变的有益工具.
- 数字工具与个性化支持的整合可能会改善MS患者的生活方式管理.
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