患有多种并发症的新生儿患有围产期登革热:病例报告和文献综述
Guanghong Li1, Xiaoqun Du1, Weibin Luo1
1Department of Pediatrics, Huadu District People's Hospital of Guangzhou, Guangzhou, China.
Frontiers in pediatrics
|November 12, 2025
概括
新生儿登革热是一种罕见的疾病,在诊断方面存在挑战,因为症状与其他围产期问题重叠. 早期的支持性护理和有针对性的测试对于管理新生儿这种树状病毒感染至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 新生儿科学 新生儿科学
- 公共卫生 公共卫生
背景情况:
- 登革热病毒感染是一个日益严重的全球健康问题,特别是在热带和亚热带地区.
- 孕妇容易感染登革热,对母亲和胎儿的健康构成风险.
- 新生儿登革热不常见,其症状往往模仿其他严重的围产期疾病,如美吸收综合征和早期出现的细菌感染.
研究的目的:
- 为了呈现一种具有非典型表现的新生儿登革热病例.
- 突出诊断在区分新生儿登革热和其他周围产生的肺部疾病的挑战.
- 强调新生儿登革热结构化诊断和管理方法的重要性.
主要方法:
- 一个案例报告,一个男婴出生于一个母亲在怀孕后期患有登革热.
- 临床评估,实验室检查 (包括登革热NS1抗原,呼吸道PCR) 和胸部X射线.
- 治疗包括支持性护理,经验性抗生素,静脉注射免疫球蛋白和阿齐思罗米.
主要成果:
- 这名新生儿出现了短呼吸,代谢性酸症,凝血病和双侧肺不透明,最初被怀疑是吸附综合征.
- 在第二天,登革热NS1抗原检测呈阳性,检测到低水平的Ureaplasma urealyticum.
- 婴儿发烧和血小板狭窄,但随着包括静脉注射免疫球蛋白在内的治疗而改善,并在稳定的状态下出院.
结论:
- 应怀疑新生儿登革热的母亲最近感染登革热在流行地区的婴儿.
- 一种系统的方法,包括早期的支持性护理,有针对性的测试,以及仔细监测凝血和血小板计数是必不可少的.
- 区分新生儿登革热与其他围产期肺部疾病需要全面评估,以确保及时和适当的管理.
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