药用植物衍生代谢物在心血管疾病中具有保护作用,其向外体途径
Liwen Fu1, Jiaxiu Han2, Rong Lu3,4
1Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in pharmacology
|November 12, 2025
概括
药用植物化合物调节外体微RNAs (miRNAs),以防止心血管疾病 (CVD). 这篇评论探讨了这些天然化合物如何增强心脏病的外体治疗.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 心脏病学 心脏病学
背景情况:
- 心血管疾病 (CVD) 构成了全球严重的健康负担,常规治疗有局限性.
- 药用植物衍生代谢物提供多目标心脏保护潜力.
- 外体微RNAs (miRNAs) 在细胞间通信和心血管疾病发病过程中至关重要.
研究的目的:
- 审查药用植物代谢物调节外体miRNAs保护心血管疾病的机制.
- 探索植物代谢物和心血管疾病中的外体治疗之间的协同作用.
主要方法:
- 对现有文献进行系统审查.
- 对特定植物代谢物的分析 (例如,坦辛IIA,阿斯特拉加索酸IV,Paeonol,Ginsenoside Rg1).
- 在心血管疾病模型中对外体miRNA调节的检查.
主要成果:
- 植物代谢物调节外体miRNA表达,以影响血管生成,炎症和血管重塑.
- 已识别的化合物通过外体miRNA通路表现出治疗作用.
- 植物代谢物和外体之间的协同作用对心血管疾病治疗有希望.
结论:
- 药用植物代谢物通过调节外体miRNAs来保护心血管疾病的潜力.
- 将植物代谢物与外体治疗结合起来,提供了一种新的治疗策略.
- 为开发针对心血管疾病的外体miRNA向药物提供了理论基础.
相关概念视频
Overview of Exosomes
3.5K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.5K
Cardiovascular Drugs: Classification based on Therapeutic Indications
4.0K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.0K


