视网膜植入物是否提供长期的疗效,安全性和改善生活质量? 一个系统的审查
Hanan B Alqahtani1,2, Marcela Votruba3,4, Justyn Regini2
1Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Therapeutic advances in ophthalmology
|November 12, 2025
概括
视网膜植入物在严重视力丧失的情况下提供一些视力恢复,改善日常任务和移动性. 然而,视力敏度仍然很低,需要更多的研究来确认长期的益处和安全性.
科学领域:
- 眼科医生 眼科 眼科
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
背景情况:
- 视网膜植入物旨在恢复患有视网膜退行性疾病的患者的视力,如视网膜色素炎 (RP) 和与年龄相关的黄斑退行 (AMD).
- 这些设备提供部分功能视觉,包括光感知和物体定位.
研究的目的:
- 系统地评估视网膜植入物的长期疗效,安全性和生活质量 (QoL) 影响.
- 该研究的重点是植入物,至少有一年的随访.
主要方法:
- 在多个数据库中按照PRISMA指南进行了系统的文献搜索.
- 包括涉及有视网膜退行症的人类受试者的研究和至少一年的随访.
- 使用CASP和JBI检查清单评估了偏差风险,并应用了叙事综合.
主要成果:
- 十三项研究分析了视网膜上部,脑下部和脑上部植入物.
- 视网膜植入物显示出视觉功能的改善,如SLT和DOM. 网膜下植入物增强了光感知和光敏度.
- 生活质量结果有所改善,特别是在移动性和日常任务方面,尽管不良事件更常见于epiretinal设备.
结论:
- 视网膜植入物提供功能视力,但不能恢复视力到20/200,接受者仍然在法律上失明.
- 偏差的高风险和潜在的安慰剂效应需要进一步的高质量研究.
- 确认长期的疗效,安全性和QoL影响需要更强有力的证据.
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