疾病和治疗中的生长激素 (综述)
Saikat Fakir1, Md Matiur Rahman Sarker1, Madan Sigdel1
1School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
Medicine international
|November 12, 2025
概括
增长激素 (GH) 调节剂,包括GHRH抗剂和体静止素类似物,在治疗与GH相关的疾病方面表现有前途. 这些疗法可能为影响大脑,眼睛,肺部和免疫系统的疾病提供新的途径.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 病理生理学 病理生理学
背景情况:
- 生长激素 (GH) 调节生长;异常水平会导致矮体,壮体,巨体和癌症等疾病.
- 增长激素释放激素 (GHRH) 和体静止素对GH调节有相反的影响.
- 为了管理与GH有关的疾病,GHRH抗体 (GHRHAnts) 和体静止素类似物 (SSAs) 正在开发.
研究的目的:
- 审查GH在人类健康和疾病中的作用.
- 总结一下最近关于GHRHAnts和SSAs保护作用的发现.
- 探索GH相关和内皮依赖功能障碍的治疗潜力.
主要方法:
- 关于GH在健康和疾病中的作用的文献综述.
- 关于GHRHAnts和FDA批准的SSAs (octreotide,lanreotide, pasireotide) 的最新发现的摘要.
- 对各种疾病中的治疗应用的证据分析.
主要成果:
- GH调节器在与GH相关的和依赖内皮质的功能障碍中表现出保护作用.
- 有证据表明,对血脑屏障失调,角膜炎,肺损伤,败血症和ARDS有潜在的益处.
- GHRHAnts和SSAs是一个有前途的治疗策略.
结论:
- GH调节器为一系列与GH相关的疾病提供了潜在的治疗方法.
- 这些药物可以治疗复杂的疾病,包括神经,眼,肺和全身炎症疾病.
- 对GH调节器的进一步研究可能会导致针对重大未满足的医疗需求的新疗法.
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