口腔微生物群和口腔状细胞癌之间是否存在联系? 对当前洞察力的审查
Luigi Santacroce1, Emilio Jirillo1, Lucrezia Bottalico2
1Section of Microbiology and Virology, Interdisciplinary Department of Medicine, School of Medicine, University of Bari 'Aldo Moro', Bari, Italy.
Journal of oral microbiology
|November 12, 2025
概括
口腔微生物群在口腔状细胞癌 (OSCC) 的发展中发挥着关键作用. 通过针对性干预,如益生菌和多,修改口腔微生物群,对预防和管理OSCC有很大的希望.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 口腔健康 口腔健康
背景情况:
- 口腔状细胞癌 (OSCC) 占口腔癌的90%以上.
- 牙周病是OSCC的重要风险因素.
- 口腔失生症是口腔微生物群体的不平衡,促进病原体过度生长,并与OSCC有关.
研究的目的:
- 审查口腔微生物群在口腔健康和疾病中的作用,特别是OSCC.
- 探索口腔微生物媒介致癌的机制.
- 突出OSCC预防和管理的潜在干预措施.
主要方法:
- 对OSCC和口腔微生物群之间的关系进行了广泛的文献搜索.
- 分析相关研究的科学数据库.
主要成果:
- 在OSCC微生物群中,表现出与细菌功能相关的基因表达改变.
- 机制包括致癌物质的产生,免疫调节和促进细胞增殖.
- 抗生素可能会增加口腔癌的风险.
结论:
- 口腔微生物群显著影响OSCC的发展和进展.
- 针对性干预改变口腔微生物群对于未来的OSCC预防和管理至关重要.
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