相关实验视频

Updated: Jan 11, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

布罗利祖马布诱导的 fulminant triple M 综合征呈现出严重的胸肌梗塞

Maia Ioana Mihon¹, Cristina Pamfil^1,2, Ruxandra Beyer³

¹Department of Rheumatology, Emergency County Clinical Hospital Cluj, Cluj-Napoca, Romania.

Medicine and pharmacy reports

|November 12, 2025

概括

免疫检查点抑制剂,如 pembrolizumab,可以引起罕见但严重的免疫相关不良事件 (irAEs). 这一案例突出了"三重M综合征" (肌炎,心肌炎,肌痛性肌痛症) 作为需要警监测的关键并发症.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
神经学神经学

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
与免疫相关的不良事件 (irAEs) 是常见的,但可能是严重的和多器官的.
很少情况下,ICI可以引发"三重M综合征":肌炎,心肌炎和肌综合征.

研究的目的:

在治疗黑色素瘤后报告严重的三重M综合征病例.
强调诊断方面的挑战,特别是ICI相关的肌痛性心肌炎和肌痛性心肌炎中缺少自身抗体.
强调早期识别和管理IRAE的重要性.

主要方法:

一个83岁的男性患有IIc阶段黑色素瘤,接受了辅助 pembrolizumab 的病例报告.
详细的临床表现包括昏迷,心房阻塞和渐进的肌肉衰弱.
停用布罗利祖马布治疗和高剂量皮质类固醇治疗.

主要成果:

患者出现了昏迷 (心房阻塞),近端肌肉衰弱,失声症和失症,与三重M综合征相一致.
尽管得到了迅速的治疗,但患者的病情迅速恶化,导致呼吸衰竭和息治疗.
诊断工作揭示了心肌炎和骨髓灰质炎,由于缺乏典型的自身抗体标志物而复杂化.

结论:

布罗利祖马布可以导致危及生命的irrAEs,包括三重M综合征.
在这种情况下,心肌炎和脑筋疲劳症可能没有特征性自身抗体,从而使诊断复杂化.
提高临床警和积极监测irAEs对于改善接受ICI患者的治疗结果至关重要.

关键词:

免疫检查点抑制剂免疫检查点抑制剂肌痛性骨髓灰质炎 (Myasthenia Gravis) 是一个严重的疾病.肌性心肌炎是一种心肌炎.肌肉性肌肉性炎症肌肉性肌肉炎

更多相关视频

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China

Published on: February 11, 2022

相关概念视频

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Dysrhythmias IV: Characteristics of Bradyarrhythmias

Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...

Decreased pulse rate

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...

Disturbances in Heart Rhythm

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...

Pulmonary Embolism I: Introduction

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...

Myocarditis III: Medical Management

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias III: Characteristics of Dysrhythmias

Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per...