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向NAD⁺ 挽救抑制PBMC炎症以改善血管认知障碍的认知功能

Ze Li¹, Hong-Yan Zhang², Rui Feng³

¹Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang (Z.L., Y.-T.W., Q.L., K.Z.).

|November 12, 2025

概括

血管认知障碍 (VCI) 涉及与血液细胞中NAD+代谢受损相关的炎症. 用5'-phosphoribosyl-pyrophosphate恢复NAD+水平改善了VCI小鼠的认知能力.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
代谢过程中的代谢.

背景情况:

血管认知障碍 (VCI) 是由血管问题引起的认知衰退.
周围血液单核细胞 (PBMCs) 在VCI中驱动炎症,但机制尚不清楚.
在VCI中,NAD+救援通路的失调可能会破坏新陈代谢和免疫平衡.

研究的目的:

调查PBMC驱动的炎症和VCI中异常的NAD+代谢之间的联系.
探索针对NAD+救援途径作为VCI治疗策略.

主要方法:

分析了使用RNA测序的VCI患者和对照组的PBMC.
在PBMC和VCI小鼠模型中测量了促炎细胞因子和NAD+救援途径组件.
用5 - 基酸 (PRPP) 评估对认知功能的治疗作用.

主要成果:

VCI PBMCs显示炎症较高,细胞内NAMPT (iNAMPT) 活性较低,NAD+水平降低,但细胞外NAMPT (eNAMPT) 较高.
抑制eNAMPT和阻断TLR4/CCR5可以减少VCI PBMC的炎症.
在VCI小鼠中,PBMC中的NAD+救援受损与炎症有关;PRPP治疗恢复了NAD+水平,减少了炎症,并改善了认知.

结论:

在PBMC中,NAD+救援受损和eNAMPT升高有助于VCI通过外周炎症致病.
通过PRPP恢复NAD+稳态,通过提高认知能力为VCI提供了潜在的治疗方法.

关键词:

认知认知认知细胞因子细胞因子恒常状态 (homeostasis) 是一种平衡状态.这是一种炎症炎症炎症炎症.尼古丁胺酸氧化转移酶是什么

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