诊断产量:什么是足够的?
Yuji Matsumoto1,2, Anne V Gonzalez3,4
1Department of Endoscopy, Respiratory Endoscopy Division.
Current opinion in pulmonary medicine
|November 12, 2025
概括
在先进的支气管镜检查中标准化诊断产量定义可以改善肺癌诊断. 优化的组织采样和分子检测确保精确,以患者为中心的结果.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 诊断支气管镜的进步旨在提高诊断产量和安全性.
- 不一致的结果定义阻碍了支气管镜研究中的数据汇集和技术比较.
研究的目的:
- 澄清诊断产量的标准化定义如何提高高级诊断支气管镜检查中的可比性和临床解释.
- 解决对支气管镜检查研究中一致结果测量的需要.
主要方法:
- 审查最近的文献和关于支气管镜诊断产量的共识陈述.
- 对优化组织采集,加工和分子测试策略的分析.
- 评估新兴技术,如EBUS-TBNA,冷活检,机器人支气管镜检查和液体活检.
主要成果:
- ATS/CHEST共识为定义和报告诊断产量提供了一个框架,使得跨研究的比较成为可能.
- 优化组织采集和处理,与支气管镜医生-病理学家合作,至关重要.
- 协调采样策略支持分子测试 (NGS);EBUS-TBNA,冷活检和机器人支气管检查提高了样品质量.
- 液体活检 (ctDNA) 提供了一种最小侵入性的辅助方法,但对低分泌疾病的敏感性有局限性.
结论:
- 遵守标准化诊断产量定义至关重要.
- 优化采样和综合分子测试确保技术创新转化为有意义的肺癌诊断.
- 以患者为中心,精确的诊断是通过标准化产量,优化采样和分子测试来实现的.
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