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Updated: Jan 11, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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G蛋白:β-阿雷斯偏差 通过GPR17对手对Gαq信号的差异调节

Jack K McDonald1,2, Aakanksha Abrol1,2, Chris Lumb1,2

  • 1Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

ACS chemical neuroscience
|November 12, 2025
PubMed
概括

GPR17对抗剂通过促进复髓化显示出治疗神经系统疾病的潜力. 这项研究揭示了有偏见的信号机制,区分了对抗剂如何影响G蛋白和β-arrestin通路,这对于开发新疗法至关重要.

关键词:
在 GPR17 中使用.发现药物的发现.带偏差是一种偏差.骨髓化 骨髓化

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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

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