非小细胞肺癌的全身疗法:在过去五十年中的突破
1Central European Lung Cancer Association, Vienna, Austria.
Current opinion in oncology
|November 12, 2025
概括
在过去的50年里,针对非小细胞肺癌 (NSCLC) 的全身治疗方法取得了显著的进步. 关键的突破包括化疗,向疗法,免疫检查点抑制剂和改善NSCLC患者的支持性护理.
科学领域:
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
- 癌症治疗方法 癌症治疗方法
背景情况:
- 非小细胞肺癌 (NSCLC) 仍然是全球癌症相关死亡的主要原因.
- 在过去的五十年里,系统疗法发生了巨大的进化,改善了患者的治疗结果.
- 了解这些进展对于当前和未来的治疗策略至关重要.
研究的目的:
- 在过去50年中,为NSCLC的系统治疗提供了重大突破的综合总结.
- 突出治疗方式的演变,从化疗到现代向性和基于免疫的方法.
- 强调在管理NSCLC时支持性护理的重要性.
主要方法:
- 本综述综合了基准研究和临床试验的发现.
- 它分析了各种系统性治疗的建立和影响.
- 该审查涵盖了NSCLC不同阶段的进展,从早期阶段到转移性疾病.
主要成果:
- 化疗已成为NSCLC所有阶段 (转移性,局部晚期和早期阶段) 的标准治疗方法.
- 氨酸激酶抑制剂 (TKIs) 现在是驱动器突变阳性NSCLC患者的缓解和辅助治疗的标准.
- 免疫检查点抑制剂 (ICI) 已成功地被整合到可操作,局部晚期和转移性NSCLC的治疗范式中.
- 通过抗emetics,造血生长因子,双酸盐和阿片类药物,在息护理方面取得了显著的改善.
结论:
- 在过去的五十年中,NSCLC系统疗法取得了重大突破.
- 这些包括化疗的出现和改进,向疗法 (TKI) 的发展,以及免疫检查点抑制剂的整合.
- 增强的支持性护理也在改善NSCLC患者的生活质量方面发挥了至关重要的作用.
更多相关视频
05:17Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
Published on: October 10, 2025
305
10:29Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
11.0K
相关概念视频
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
