胺/胺在缓解术后疲劳方面的有效性:系统性审查
Qijing Liu1, Ying Liu1, Qian Fu1
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, China.
International journal of clinical pharmacy
|November 12, 2025
概括
胺和胺显示了缓解术后疲劳 (POF) 的潜力,特别是在重大腹部手术后. 然而,由于证据有限和研究变异,需要更多高质量的研究.
科学领域:
- 麻醉学和疼痛管理
- 手术瘤学手术瘤学
- 关键护理医学 关键护理医学
背景情况:
- 手术后疲劳 (POF) 是手术后的一种严重的临床并发症.
- 胺类药物和胺类药物在治疗POF方面表现有前途,但缺乏系统的证据.
研究的目的:
- 系统地评估外科手术期间的胺/胺在减少手术患者的POF中的有效性.
- 综合当前关于胺/胺在治疗术后疲劳中的作用的证据.
主要方法:
- 按照PRISMA指导方针进行系统审查,并在PROSPERO.中进行前性注册.
- 搜索了主要的数据库 (PubMed,Embase,Cochrane,Web of Science) 相关的临床研究.
- 包括前性/后性研究,比较胺/胺与对照剂,重点关注疲劳结果;由于异质性的叙述综合.
主要成果:
- 包括9项研究 (1606名患者):7项RCT和2项观察性研究.
- 胺/乙胺在主要腹部手术中显示出改善POF的潜力 (低确定性证据).
- 在乳腺或骨科手术中没有观察到显著的益处;对于胃肠内镜检查,结果不一致.
结论:
- 胺/胺可能减轻POF,特别是在主要的腹部手术中,但证据有限,需要谨慎解释.
- 研究设计的异质性,疲劳评估和小样本大小需要仔细考虑研究结果.
- 高质量的RCT对于确认有效性和确定POF管理中胺/胺的最佳剂量方案至关重要.
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