在马尔默饮食和癌症研究队列中,古石器时代饮食分量与全身低度慢性炎症之间的关联
Pedro Carrera-Bastos1,2, Björn Rydhög3,4, Yvonne Granfeldt5
1Center for Primary Health Care Research, Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden. pedro.carrera_bastos@med.lu.se.
European journal of nutrition
|November 12, 2025
概括
高旧石器时代饮食分数 (PDF) 的摄入与较低的系统性低度慢性炎症 (SLGCI) 有关. 这表明SLGCI可能会调解PDF.
科学领域:
- 营养科学 营养科学
- 炎症生物学 炎症生物学
- 心血管健康 心血管健康
背景情况:
- 古石器时代饮食分数 (PDF) 量化了古石器时代饮食食物的摄入量.
- 马尔默饮食和癌症研究 (MDCS) 之前的研究将较高的PDF和较低的全身低度慢性炎症 (SLGCI) 与心脏代谢疾病的减少联系起来.
- 了解PDF和SLGCI之间的关系对于心脏代谢健康研究至关重要.
研究的目的:
- 调查古石器时代饮食分量 (PDF) 与系统性低度慢性炎症 (SLGCI) 生物标志物之间的关联.
- 探索SLGCI在PDF和心脏代谢结果之间的关系中的潜在调解作用.
主要方法:
- 分析了来自马尔默饮食和癌症研究 (MDCS) 的大量队列 (n=23,250),不包括先前患有心脏代谢疾病的参与者.
- 根据综合饮食评估数据计算PDF.
- SLGCI的生物标志物包括总白细胞计数 (TLC),中性粒细胞与淋巴细胞的比率 (NLR) 和C反应蛋白 (CRP).
主要成果:
- 在完全调整后,观察到PDF和所有测量的SLGCI生物标志物 (TLC,NLR和lnCRP) 之间存在显著的反向关联.
- 更高的PDF始终与较低水平的炎症标志物有关.
- 在炎症生物标志物本身中发现了弱但显著的相关性.
结论:
- 古石器时代的饮食分量 (PDF) 与系统性低级慢性炎症 (SLGCI) 的生物标志物相反相关.
- 在PDF与心脏代谢健康之间观察到的关联中,SLGCI可能起着调解作用.
- 由于研究的横截面设计和CRP测量滞后,研究结果应谨慎解释.
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