角膜整形术后的角膜炎:风险修饰因子,微生物耐药性和COVID-19时代的结果
Natalie Elizabeth Allen1, Rachael Niederer2, Akilesh Gokul2
1Department of Ophthalmology, Faculty of Medical & Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand. Natalie.allen@auckland.ac.nz.
International ophthalmology
|November 12, 2025
概括
角膜移植接受者在手术后5年内面临6%的角膜炎风险,其中亚裔,年龄较大和不良合规性是关键风险因素. 内皮角质整形可以降低这种风险,而角质炎显著增加了移植失败.
科学领域:
- 眼科医生 眼科 眼科
- 移植手术 移植手术
- 传染性疾病 传染性疾病
背景情况:
- 角膜移植是恢复视力的常见手术.
- 角膜炎,角膜的炎症,是角膜移植后的一个重大并发症.
- 了解风险因素和结果对于改善移植存活率至关重要.
研究的目的:
- 在新西兰奥克兰进行角膜移植后评估角膜炎的发病率和风险因素.
- 识别致病生物并评估它们的抗生素耐药性模式.
- 为了确定角膜炎对角膜移植结果的影响.
主要方法:
- 对2010年至2022年期间在奥克兰进行的所有角膜移植进行了回顾性审查.
- 对人口统计数据,移植类型,合规性和随访等临床记录的分析.
- 微生物培养和抗生素敏感性测试用于角膜炎病例.
主要成果:
- 在移植后的五年内,角膜炎的累积发病率达到6.0%.
- 细菌感染是最常见的原因 (72.6%).
- 亚洲族裔,年龄增长和治疗不合格是炎的重要危险因素. 与透式角膜整形相比,内皮角膜整形的风险较低.
- 角膜炎显著增加了移植失败的风险 (OR 2.5).
结论:
- 在奥克兰进行角膜移植时,尤其是在长期内,还存在大量角膜炎的风险.
- 虽然抗生素耐药性较低,但患者的服从性和移植类型是影响状炎风险的可改变因素.
- 预防和治疗角膜炎对于减少角膜移植失败至关重要.
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