功能组作为功能驱动因素:医学应用的湿性物质中的结构-活性关系
Pengfei Xin1, Qingmei Liu2, Kuanshou Zhang3
1Department of Stomatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China. xinpengfei@sxbqeh.com.cn.
Environmental geochemistry and health
|November 12, 2025
概括
性物质 (HSs) 显示出治疗潜力,由特定的功能组驱动. 需要进一步的研究,以了解它们的结构-活性关系,以适用于现代医学应用.
科学领域:
- * 环境科学和药理学
- *跨学科的研究桥梁化学,生物学和医学.
背景情况:
- * 性物质 (HSs) 具有历史性的药用,但缺乏机理性的理解.
- * 由于缺乏结构-活性关系知识,对现代治疗方法的翻译有限.
- * 研究中的学科不平衡,环境科学占据了制药学和药学的主导地位.
研究的目的:
- * 分析医学中的湿性物质的研究格局,使用文献计量.
- * 批判性地审查HSs的结构-活性关系,用于治疗应用.
- * 确定基于HS的治疗方法的研究缺口和未来方向.
主要方法:
- *对1860个Web of Science出版物 (2000-2025) 的图书统计分析.
- * 批评文献综述,重点关注HS的功能组和生物活性.
- *研究重点的趋势分析随着时间的推移而变化.
主要成果:
- *研究重点从吸附转向基于HS的纳米载体和光热疗法.
- * 确定了关键的功能组:碳酸,酸,子部分和两性结构.
- * 特定群体与pH响应性输送,金属化,氧化还原调节和提高药物的生物可用性相关.
结论:
- *HSs拥有各种功能组,对于它们的生物活动至关重要.
- *有限的临床前验证阻碍了HSs转化为治疗药物.
- *未来的研究需要标准化HS特征,临床试验和跨学科合作.
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