来自宿主的Pediococcus Acidilactici GLP06 减轻了与抗生素相关的狗腹
Yuanyuan Zhang1, Mengdi Zhao1,2, Shuang Liang1
1College of Animal Science and Technology, Qingdao Agricultural University, Qingdao, 266109, China.
Probiotics and antimicrobial proteins
|November 12, 2025
概括
来自狗的Pediococcus acidilactici GLP06有效地减轻了狗的抗生素相关腹 (AAD). 这种益生菌恢复了肠道微生物平衡,改善了肠道屏障功能,减少了炎症,为狗AAD提供了潜在的治疗方法.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 抗生素相关性腹 (AAD) 是对狗的抗生素治疗的常见不良影响,通常是由肠道失调引起的.
- 益生菌正在探索通过恢复肠道微生物群平衡来管理AAD.
- 对于犬类AAD,来自犬类的Pediococcus acidilactici GLP06的疗效仍未得到研究.
研究的目的:
- 评估Pediococcus acidilactici GLP06对比格尔犬抗生素诱导的腹的治疗作用.
- 研究P. acidilactici GLP06对肠道微生物群组成,短链脂肪酸 (SCFA) 生产和宿主新陈代谢的影响.
主要方法:
- 在比格尔犬中抗生素诱导的腹模型.
- 评估便分数,血清生化标志物 (二胺氧化酶,TNF-α).
- 16S rRNA测序用于肠道微生物群分析,SCFA量化和非目标便代谢.
主要成果:
- P. acidilactici GLP06的使用显著改善了便分数和减少了炎症标志物.
- 益生菌治疗增强了肠道微生物的多样性和丰富性,并增加了诸如Lactobacillus和Bifidobacterium之类的有益细菌.
- 观察到SCFA (酸,黄油酸) 的产量增加和抗生素破坏的代谢途径的恢复.
结论:
- Pediococcus acidilactici GLP06通过改善肠道屏障功能,调节肠道微生物群,恢复新陈代谢平衡,有效地减轻犬类AAD.
- 这种益生菌显示出临床应用的潜力,用于预防和治疗狗的AAD.
- 这项研究提供了科学证据,支持P. acidilactici GLP06作为对狗肠道健康的可行的益生菌.
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