Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

MicroRNAs01:22

MicroRNAs

3.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
MicroRNAs01:22

MicroRNAs

23.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.9K
Experimental RNAi02:15

Experimental RNAi

7.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
7.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The quality and reliability of short videos about cervical spondylosis on TikTok and Redbook: a cross-sectional study.

BMC musculoskeletal disorders·2026
Same author

Impact of continuous serratus plane analgesia on quality of recovery after video-assisted thoracic surgery: a prospective double-blind, randomized, placebo-controlled trial.

Regional anesthesia and pain medicine·2026
Same author

High-flow nasal cannula for hypoxia in the post-anesthetic recovery unit: A systematic review and meta-analysis.

World journal of critical care medicine·2026
Same author

HIF-1α/HO-1 Axis Promotes Ferroptosis and Impairs Periodontal Tissue Repair in Periodontitis.

Journal of clinical periodontology·2026
Same author

The potential role of sex related differences of the microbiome and its impact on calcific aortic stenosis: a narrative review.

Biology of sex differences·2026
Same author

miRNA-26b Is Associated with Increased Connexin-40 Expression in Endothelial Cells Under Flow Conditions.

International journal of molecular sciences·2026

相关实验视频

Updated: Jan 11, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.9K

微RNA-26b-/-增加了动脉样硬化,而模仿载荷的纳米粒子减少了动脉样生成.

Linsey J F Peters1,2, Kiril Bidzhekov1, Andrea Bonnin-Marquez2,3

  • 1Institute for Cardiovascular Prevention (IPEK), LMU Munich, 80336 Munich, Germany.

Cardiovascular research
|November 12, 2025
PubMed
概括

微RNA-26b (miR-26b) 具有动脉动脉保护作用,通过抑制炎症来减少动脉样硬化病变的形成. miR-26b模仿载荷的纳米颗粒显示出治疗动脉样硬化治疗的治疗潜力.

关键词:
动脉样硬化是一种动脉样硬化.脂质纳米颗粒的使用方法巨细胞是一个巨细胞.微型RNA-26b是什么意思

更多相关视频

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
08:01

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

7.7K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

720

相关实验视频

Last Updated: Jan 11, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.9K
Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
08:01

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

7.7K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

720

科学领域:

  • 心血管生物学 心血管生物学
  • 分子医学是分子医学.
  • 微RNA治疗药物 微RNA治疗药物

背景情况:

  • 微RNAs (miRs) 涉及到动脉样硬化病变的发生.
  • 在人体动脉样硬化斑块中,miR-26b的升高调节.
  • 在动脉样硬化中miR-26b的特定作用和治疗潜力需要阐明.

研究的目的:

  • 研究miR-26b对动脉样硬化发展的细胞特异性影响.
  • 在临床前模型中确定miR-26b的治疗潜力.

主要方法:

  • 在西方类型的饮食中使用了Apoe- / - Mir26b- / - 和髓状腺特异性淘汰赛小鼠.
  • 评估动脉样硬化斑块的大小,表型和巨细胞功能.
  • 使用的脂质纳米颗粒 (LNP) 在体外和体内模仿miR-26b的输送.

主要成果:

  • Apoe-/-Mir26b-/-小鼠在大动脉门中显著增加了动脉样硬化病变的大小.
  • 骨髓细胞中miR-26b的损失促进了亲炎性巨细胞表型和改变了斑块组成.
  • 通过LNP传递的miR-26b模仿物挽救了这些动脉样硬化作用,并证明了治疗潜力.

结论:

  • miR-26b通过减少病变形成,炎症和促进原蛋白分解,起到关键的动脉动脉保护作用.
  • miR-26b模仿载荷的LNP代表了动脉样硬化的一种有前途的治疗策略.